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KMID : 0043320060290090741
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Archives of Pharmacal Research
2006 Volume.29 No. 9 p.741 ~ p.745
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Estrogenic Activity of Furanocoumarins Isolated from Angelica dahurica
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Piao Xiang Lan
Kang Tak-Lim
Hwang Gwi-Seo
Park Jeong-Hill
Yoo Hye-Hyun
Kim Hyun-Young
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Abstract
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In our efforts to discover novel phytoestrogens to treat menopausal symptoms, eleven furanocoumarins were isolated from Angelica dahurica and tested for their estrogenic activity on the Ishikawa cell line. Among the compounds tested, 9-hydroxy-4-methoxypsoralen and alloisoimperatorin showed strong abilities to induce alkaline phosphatase (AP) with EC50 values of 1.1 and 0.8 μg/mL, respectively, whereas the other nine furanocoumarins were weakly or only slightly active.
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KEYWORD
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Angelica dahurica, Umbelliferae, Furanocoumarin, Estrogenic activity
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